Synthesis of some new isoxazoline derivatives as possible anti-Candida agents.

The isoxazolines have been reported to possess a variety of significant and diverse pharmacological activities such as antifungal (1, 2), anti-HIV (3), anti-bacterial (4), caspase inhibitory (5), antimuscarinic (6), anti-inflammatory (7), anticancer (8) and anti-depressant (9) activity. On the other hand, the object of antifungal drug discovery has become a subject of greater challenge due to increasing incidences of fungal drug resistance. In the past decade, number of patients diagnosed with fungal infections have increased drastically, whereas, relatively very few clinically useful drugs were discovered. As a part of our ongoing antimicrobial drug design program, quantitative structure activity relationships (QSAR) studies were performed (10). The predictive 2D and 3D QSAR studies revealed that some simple isoxazoline derivatives possessed structural and electro-chemical properties to be suitable as effective antiCandida agents. Hence, in light of these findings and to check the hypothesis of QSAR studies, it was decided to synthesize certain 3-phenylamino (substituted phenyl) isoxazolines and evaluate them for anti-Candida activity.